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upload/wll/ENTER/Science/Biology/Health/1 - More Health Books/Enzymatic Reaction Mechanisms - P. Frey, A. Hegeman (Oxford, 2007) WW.pdf
Enzymatic Reaction Mechanisms 🔍
Perry A. Frey and Adrian D. Hegeman Oxford University Press; Oxford University Press, USA, Illustrated, 1, PS, 2007
英语 [en] · PDF · 34.0MB · 2007 · 📘 非小说类图书 · 🚀/lgli/lgrs/nexusstc/upload/zlib · Save
描述
Books dealing with the mechanisms of enzymatic reactions were written a generation ago. They included volumes entitled Bioorganic Mechanisms, I and II by T.C. Bruice and S.J. Benkovic, published in 1965, the volume entitled Catalysis in Chemistry and Enzymology by W.P. Jencks in 1969, and the volume entitled Enzymatic Reaction Mechanisms by C.T. Walsh in 1979. The Walsh book was based on the course taught by W.P. Jencks and R.H. Abeles at Brandeis University in the 1960's and 1970's. By the late 1970's, much more could be included about the structures of enzymes and the kinetics and mechanisms of enzymatic reactions themselves, and less emphasis was placed on chemical models. Walshs book was widely used in courses on enzymatic mechanisms for many years. Much has happened in the field of mechanistic enzymology in the past 15 to 20 years. Walshs book is both out-of-date and out-of-focus in todays world of enzymatic mechanisms. There is no longer a single volume or a small collection of volumes to which students can be directed to obtain a clear understanding of the state of knowledge regarding the chemicals mechanisms by which enzymes catalyze biological reactions. There is no single volume to which medicinal chemists and biotechnologists can refer on the subject of enzymatic mechanisms. Practitioners in the field have recognized a need for a new book on enzymatic mechanisms for more than ten years, and several, including Walsh, have considered undertaking to modernize Walshs book. However, these good intentions have been abandoned for one reason or another. The great size of the knowledge base in mechanistic enzymology has been a deterrent. It seems too large a subject for a single author, and it is difficult for several authors to coordinate their work to mutual satisfaction. This text by Perry A. Frey and Adrian D. Hegeman accomplishes this feat, producing the long-awaited replacement for Walshs classic text.
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upload/arabic/New-Upload/English-pdf/Chemistry -3/Biochemistry/Enzymatic Reaction Mechanisms - Frey.pdf
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upload/wll/ENTER/Science/Chemistry/1 - More books on Biochemistry/Enzymatic Reaction Mechanisms - Frey.pdf
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lgli/V:\!GST\DVD 17 - Great Science Textbooks DVD Library 2007 - Update Apr 2009\Biology\Biochemistry\Frey - Enzymatic Reaction Mechanisms (Oxford, 2007).pdf
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lgrsnf/V:\!GST\DVD 17 - Great Science Textbooks DVD Library 2007 - Update Apr 2009\Biology\Biochemistry\Frey - Enzymatic Reaction Mechanisms (Oxford, 2007).pdf
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nexusstc/Enzymatic Reaction Mechanisms/9d96468bf70eb418512b2c8ab304cab1.pdf
备用文件名
zlib/Medicine/Perry A. Frey, Adrian D. Hegeman/Enzymatic Reaction Mechanisms_550347.pdf
备选标题
0195122585.pdf
备选作者
Frey, Perry A., Hegeman, Adrian D.
备选作者
PScript5.dll Version 5.2
备用出版商
IRL Press at Oxford University Press
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Oxford Institute for Energy Studies
备用出版商
German Historical Institute London
备用出版商
Ebsco Publishing
备用版本
United Kingdom and Ireland, United Kingdom
备用版本
Oxford University Press USA, Oxford, 2007
备用版本
United States, United States of America
备用版本
New York, Oxford, New York State, 2006
备用版本
OUP E-Books, Oxford ; New York, 2007
元数据中的注释
Great Science Textbooks DVD Library 2007 -- Update Apr 2009
元数据中的注释
lg122240
元数据中的注释
producers:
Acrobat Distiller 6.0 (Windows)
元数据中的注释
{"edition":"1","isbns":["0195122585","0197565468","1429459174","9780195122589","9780197565469","9781429459174"],"last_page":852,"publisher":"Oxford University Press"}
备用描述
The past fifteen years have seen a tremendous surge in knowledge about enzymatic catalysis. This is largely due to the empowerment of this vibrant and mature field by the fruits of methodological advances. Enzymatic Reaction Mechanisms presents the current state of understanding about mechanisms of enzymatic catalysis, focusing on the chemical mechanisms facilitated by enzymes.Chapters 1 through 5 introduce most of the conceptual and theoretical background for catalytic theory; kinetics; and the chemistry of coenzyme-action, including classical vitamin-related organic coenzymes and the more numerous metallo-coenzymes and cofactors, among others. Each of these chapters includes a few brief case studies of individual enzymes. Chapters 6 through 17 focus on types of enzymatic reactions and the strategies employed in catalysis. Each chapter takes up a reaction type, such as acyl transfer or phosphotransfer. A chapter begins with the basic chemistry of the reaction type, emphasizing mechanisms. Then, brief case studies of relevant and extensively researched enzymes reveal the biocatalytic strategies for each reaction type. The case studies include essential mechanistic and structural information, including global enzyme structures and expanded views of active sites. The topical chapters begin with the kinetically simple one-substrate reactions and progress chapter by chapter to two- and three-substrate transferases, synthetases, and oxygenases. The book concludes with a series of case studies of complex enzymes. More than one hundred case studies are presented throughout the book, with chemical, kinetic, and structure-function information and both global structures and close-up views of the active sites.
备用描述
1. Enzymes and Catalytic Mechanisms. 2. Kinetics of Enzymatic. 3. Coenzymes I: Organic Coenzymes. 4. Coenzymes II: Metallic Coenzymes. 5. Enzyme Inhibition. 6. ACYL Group Transfer: Proteases. 7. Isomerization. 8. Decarboxylation and Carboxylation. 9. Addition and Elimination. 10. Phosphotransfer AND NucleotidylTransfer. 11. ATP-Dependent Synthetases and Lifases. 12. Glycosyl Group Transferases. 13. Nitrogen and Sulfur Transferases. 14. Carbon-Carbon Condensation and Cleavage. 15. Alkyltransferases. 16. Oxidoreductases. 17. Oxidases and Oxygenases. 18. Complex Enzymes
备用描述
Enzymes and catalytic mechanisms
Kinetics of enzymatic
Coenzymes I : organic coenzymes
Coenzymes II : metallic coenzymes
Enzyme inhibition
ACYL group transfer: proteases
Isomerization
Decarboxylation and carboxylation
Addition and elimination
Phosphotransfer and nucleotidyltransfer
ATP-dependent synthetases and ligases
Glycosyl group transferases
Nitrogen and sulfur transferases
Carbon-carbon condensation and cleavage
Alkyltransferases
Oxidoreductases
Oxidases and oxygenases
Complex enzymes.
备用描述
Much has happened in the field of mechanistic enzymology in the past 15 to 20 years, but books dealing with the mechanisms of enzymatic reactions were writtena generation ago and have not been updated. There is no single volume on enzymatic mechanismsto which medicinal chemists and biotechnologists can refer. As the modern day replacement for C.T. Walsh's classic 1979 book on the subject, Frey and Hegeman's text promises to be an instant success
备用描述
Much has happened in the field of mechanistic enzymology in the past 15 to 20 years, but books dealing with the mechanisms of enzymatic reactions were written a generation ago and have not been updated. There is no single volume on enzymatic mechanisms to which medicinal chemists and biotechnologists can refer. As the modern day replacement for C.T. Walsh's classic 1979 book on the subject, Frey and Hegeman's text promises to be a success
开源日期
2009-10-26
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